Casa Playa Comforts - Vacation Rentals in Historic Southwest

Magical Nest Hideaway From US $120
         

10.0 (153 Reviews)
House
  • Air Conditioner
  • Parking
  • TV
Covered By Faith Downtown- Blessing House From US $129
         

9.7 (5 Reviews)
House
  • Air Conditioner
  • Parking
  • Designated Smoking Area
Home2 Suites by Hilton Rochester Mayo Clinic Area From US $156
         

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9.6 (995 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
A Luxury Bungalow Near Mayo Clinic From US $192
         

10.0 (67 Reviews)
House
  • Air Conditioner
  • Parking
  • TV
Luxurious 5-BR Retreat with Gym & Game Area From US $563
         

10.0 (39 Reviews)
House
  • Air Conditioner
  • TV
  • Balcony/Terrace

Luxury Places to Stay in Historic Southwest

Over 323+ Luxury Places to Stay in or Near Historic Southwest
RARE! Pool, hot tub, garden &chickens! 4m to Mayo From US $846
         

10.0 (1 Review)
House
  • Pool
  • Security/Safety
  • Barbecue/Outdoor Cooking
Beautiful, Private, Nature & Hot tub! 4 miles to Mayo From US $709
         

10.0 (3 Reviews)
House
  • Air Conditioner
  • Security/Safety
  • Bedding/Linens
Villa LaRhea From US $671
         

9.6 (4 Reviews)
House
  • Air Conditioner
  • Parking
  • TV
Luxury Stay/Theater/No step entry/Dogs Welcome From US $577
         

10.0 (24 Reviews)
House
  • Air Conditioner
  • Pet Friendly
  • TV
Welcome to our modern and stylish 4 bedrooms in Rochester. From US $539
         

10.0 (3 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly

Top-Rated Vacation Rentals with a Pool in Historic Southwest

Over 65+ Top-Rated Vacation Rentals with a Pool in or Near Historic Southwest
Newly Remodeled Home 1 mile from Mayo Clinic From US $149
         

10.0 (8 Reviews)
House
  • Air Conditioner
  • Parking
  • Pool
Spark by Hilton Rochester South From US $95
         

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9.2 (517 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
Home2 Suites by Hilton Rochester Mayo Clinic Area From US $135
         

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9.2 (207 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pet Friendly
The Berkman From US $201
         

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9.2 (79 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pet Friendly
Hampton Inn Rochester-South From US $115
         

9.0 (1006 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
Sleep Inn & Suites West-Near Medical Center From US $98
         

9.0 (660 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
Courtyard Rochester Mayo Clinic Area/Saint Marys From US $151
         

TownePlace Suites by Marriott Rochester From US $120
         

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8.8 (591 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool

Pet-Friendly Vacation Rentals in Historic Southwest

Over 114+ Pet-Friendly Vacation Rentals in or Near Historic Southwest
1742 Uptown/Stylish w/Updates, 3BD, Walk to Mayo, Pet Friendly From US $294
         

☆Dee Dee's Den a Dharma Dwellings Parent Company☆ From US $270
         

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10.0 (2 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
The Berkman From US $278
         

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9.6 (415 Reviews)
Apartment
  • Air Conditioner
  • Parking
  • Pet Friendly
☆Poppy's Paradise: A Dharma Dwellings Designed Home☆ From US $213
         

10.0 (20 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
Cozy 2BR/Close to Mayo Clinic/Full Kitchen & Private Backyard From US $171
         

10.0 (13 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic! From US $178
         

10.0 (10 Reviews)
Apartment
  • Air Conditioner
  • Parking
  • Pet Friendly
Lux 3 BR mins to Mayo & Dwtwn I Charming Haven From US $260
         

10.0 (9 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly

Large Vacation Homes & Villas in Historic Southwest

Over 24+ Large Vacation Homes & Villas in or Near Historic Southwest
Luxury Home From US $199
         

New
Villa
  • Air Conditioner
  • Parking
  • Child Friendly
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆ From US $288
         

9.8 (52 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
3 blks to St. Marys 3,800 sq ft CoveredByFaith From US $173
         

9.6 (26 Reviews)
House
  • Air Conditioner
  • TV
  • Balcony/Terrace
No Steps Close to Mayo & Shopping Covered By Faith From US $206
         

9.4 (45 Reviews)
House
  • Air Conditioner
  • Pet Friendly
  • TV
MN Comforts The Heart 4Bd/2Bth, 12min to Mayo From US $264
         

New
House
  • Air Conditioner
  • Security/Safety
  • Bedding/Linens

Wheelchair Accessible Vacation Homes in Historic Southwest

Over 70+ Wheelchair Accessible Vacation Homes in or Near Historic Southwest
Covered By Faith Downtown Rentals- Trust House From US $179
         

10.0 (1 Review)
House
  • Air Conditioner
  • Parking
  • Designated Smoking Area
Candlewood Suites Rochester Mayo Clinic Area by IHG From US $123
         

2 Bedroom 2 Bath Apartment Near Mayo, Park Free! From US $230
         

10.0 (1 Review)
Apartment
  • Air Conditioner
  • Parking
  • Pet Friendly

Historic Southwest Vacation Rentals and Airbnb Places to Stay Under $200

Over 191+ Historic Southwest Vacation Rentals and Airbnb Places to Stay Under $200
The Family Haven From US $116
         

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10.0 (2 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
Econo Lodge Mayo Clinic Area From US $84
         

9.0 (1003 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Designated Smoking Area
2bed/2bath Large bright and comfortable home From US $167
         

10.0 (6 Reviews)
House
  • Air Conditioner
  • Parking
  • TV
Charming 3-bedroom house with AC in lovely Rochester-Mayo Clinic From US $194
         

1 mile Mayo 2 step entry Encourage Covered ByFaith From US $135
         

10.0 (2 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
2 step entry 1 mile to Mayo CoveredByFaith Inspire From US $129
         

10.0 (2 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly

Instantly Bookable Vacation Homes in Historic Southwest

Over 138+ Instantly Bookable Vacation Homes in or Near Historic Southwest
Peaceful Home near Cascade Lake 8 min to Mayo, 3 min to St. Mary's From US $319
         

CherryWood Home-2 miles from Downtown & Mayo Clinic From US $274
         

10.0 (4 Reviews)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
Bloom Bungalow/Charming 2-bedroom house, pet friendly, 7 blks to Mayo Clinic From US $270
         

About Historic Southwest Vacation Rentals

With more than 332 Historic Southwest vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Casaplayacomforts and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at a rental property in Historic Southwest.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With Casaplayacomforts Historic Southwest, you have the flexibility of comparing different options of various deals with a single click. Looking for a rental by owner with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner, and other popular Airbnb-style properties in Historic Southwest. Places to stay near Historic Southwest are 800.75 ft² on average, with prices averaging US $193 a night.

Casaplayacomforts makes it easy and safe to find and compare vacation rentals in Historic Southwest with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Top Rental Accommodation Types in Historic Southwest

Type Count
Vacation Homes 211
Hotels 55
Holiday Apartments 45
Villas 3
Cabin Rentals 2
Cottages 2
Others 1

Use these Quick Filters to Find a Vacation Rental in Historic Southwest

Pro Tip: Casaplayacomforts makes it easy to compare the best listings on Casaplayacomforts homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Casaplayacomforts homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Historic Southwest.

Weather in Historic Southwest

View the weather forecast for Historic Southwest before booking your Historic Southwest Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Historic Southwest Vacation Rental Frequently Asked Questions

What are the top vacation rentals in Historic Southwest?
How many vacation rentals are available in Historic Southwest?

Currently, the total number of properties listed in 2026 is over 332 in the Historic Southwest area, and still counting. By aggregating listings from multiple websites, offers an immense amount of choice of the best properties in Historic Southwest.